The mural of St. Benedict shows him holding a book that readsora et labora, which means "pray and work." This directive is from the Rule of St. Benedict and has become a motto associated with Benedictines since the earliest centuries.

In the upper right corner of the mural is the Archabbey Church, depicted with a monk tilling a field. Like many Benedictine monasteries, Saint Meinrad formerly shared in the traditional work of farming. Today, while the Archabbey still owns farmland, all but a small garden is leased to local farmers.

Saint Meinrad's primary apostolic work is the graduate-level Seminary and School of Theology, which provides education and formation for priests, permanent deacons and lay ministers. In the lower right corner of the mural are young seminarians studying from books, yet also learning about art. Arts and crafts have been an important part of monastic life as well. Several of the monks are artisans: painters, weavers, potters, carpenters and gardeners.

The left side of the mural is dedicated to the Liturgy of the Hours and daily Mass. Communal prayer is a major element of the life of a monk. The monks gather in the Archabbey Church five times a day to pray the psalms or celebrate Mass. You can also see three monks in choir. The monk with a closed book is a self-portrait of the artist, Dom Gregory de Wit.